The use of molecular line probe assays for the detection of resistance to second-line anti-tuberculosis drugs: policy guidance

World Health Organization.

This document provides a summary of the evidence and recommendations for the use of SL-LPA for the detection of mutations associated with resistance to fluoroquinolones and SLID in patients with RR-TB and/or MDR-TB. The objectives of this policy guidance are to assess and compare the diagnostic accuracy ...

Tuberculosis Resistente a Múltiples Medicamentos/diagnóstico, Antibióticos Antituberculosos/farmacología, Técnicas de Sonda Molecular, Pruebas de Sensibilidad Microbiana, Fluoroquinolonas/uso terapéutico, Farmacorresistencia Bacteriana/genética, Genotipo, Mutación, Tuberculosis Resistente a Múltiples Medicamentos/genética, Mycobacterium tuberculosis/efectos de los fármacos, Mycobacterium tuberculosis/genética

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The use of molecular line probe assays for the detection of resistance to isoniazid and rifampicin

World Health Organization.

Tuberculosis (TB) remains a large-scale public health problem. Key global priorities for TB care and control include improving case-detection and detecting cases earlier, including cases of smear-negative disease. This document updates existing WHO policy on the use of molecular LPAs for detecting MTBC a...

Técnicas de Sonda Molecular, Rifamicinas/uso terapéutico, Isoniazida/uso terapéutico, Tuberculosis Resistente a Múltiples Medicamentos/diagnóstico, Antituberculosos/uso terapéutico, Isoniazida/farmacología, Rifampin/farmacología, Mycobacterium tuberculosis/efectos de los fármacos, Farmacorresistencia Bacteriana, Reproducibilidad de los Resultados

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The use of loop-mediated isothermal amplification (TB-LAMP) for the diagnosis of pulmonary tuberculosis: policy guidance

World Health Organization.

Tuberculosis (TB) remains a large-scale public health problem. Key global priorities for TB care and control include improving case-detection and detecting patients earlier, particularly patients with smear-negative TB disease. This document provides a pragmatic summary of the evidence and recommendation...

Técnicas de Amplificación de Ácido Nucleico, Tuberculosis Pulmonar/diagnóstico, Mycobacterium tuberculosis/genética, Sensibilidad y Especificidad

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Noncommercial culture and drug-susceptibility testing methods for screening patients at risk for multidrug-resistant tuberculosis: policy statement

World Health Organization.

Commercial liquid culture systems and molecular line-probe assays have been endorsed by the World Health Organization (WHO) as gold standards for rapid detection of multidrug-resistant (MDR) tuberculosis (TB); however, because of technical complexity, cost and the requirement for sophisticated laboratory...

Tuberculosis Resistente a Múltiples Medicamentos, Antituberculosos, Pruebas de Sensibilidad Microbiana, Mycobacterium tuberculosis/aislamiento & purificación

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Policy statement: automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF system

World Health Organization.

Earlier and improved tuberculosis (TB) case detection - including smear-negative disease, often associated with HIV co-infection - as well as expanded capacity to diagnose multidrug-resistant tuberculosis (MDR-TB) are global priorities for TB control. Conventional laboratory methods are slow and cumberso...

Tuberculosis/diagnóstico, Mycobacterium tuberculosis/aislamiento & purificación, Infecciones por VIH/diagnóstico, Sensibilidad y Especificidad, Tuberculosis Resistente a Múltiples Medicamentos, Rifampin/farmacología

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